What’s going on with Selma Blair? The actress has issued a public apology for an incident earlier this week when she was rushed off an international flight on a stretcher after exhibiting erratic behavior, which she says was caused by an accidental combination of booze and prescription pills.

“I made a big mistake yesterday,” said Blair, who is best known for her roles in Cruel Intentions and Legally Blonde. “After a lovely trip with my son and his Dad, I mixed alcohol with medication, and that caused me to black out and led me to say and do things that I deeply regret.”

On Monday, the 43-year-old actress had been traveling from Cancún to Los Angeles with her 4-year-old son Arthur and his father, her ex-boyfriend Jason Bleick, when she reportedly had an “outburst” on board the plane. After Blair began “screaming uncontrollably,” according to TMZ, “the nurses—one standing over her and one seated—propped her head up with a pillow and gave her oxygen to calm her down.” Some fellow passengers told TMZ they saw her mixing pills with wine.

When the flight landed in Los Angeles, Blair was taken to a nearby hospital on a stretcher. "She was met by paramedics at LAX as soon as her plane arrived," a source told People. "It looks like she had taken a combination of prescription medication with alcohol. We don't know what sort of prescription medications." The actress has no confirmed history of addiction, but was rumored to have completed a 30-day stint in rehab in 2006 to address her drug abuse. And according to Radar, she “reportedly entered rehab during the last year.”

In her statement, published Tuesday in Vanity Fair, Blair said she was thankful that her son was asleep during the incident. “My son was with his Dad asleep with his headphones on, so there is that saving grace,” she said. “I take this very seriously, and I apologize to all of the passengers and crew that I disturbed and am thankful to all of the people who helped me in the aftermath.” She added: “I am a flawed human being who makes mistakes and am filled with shame over this incident. I am truly very sorry.”