Celebrex May Reduce Lung Cancer Threat in Ex-Smokers | The Fix
facebook twitter RSS
HOT TOPICS: Alcoholism  Addiction  AA  Cocaine  Heroin

Celebrex May Reduce Lung Cancer Threat in Ex-Smokers

Controversial arthritis drug cuts down on a crucial protein needed for tumor growth.


Only 15% still alive 5 years later.
Photo via thinkstockphotos

By Dirk Hanson


| Share

All smokers, both those who are abstinent and those still puffing away, harbor the same primal fear: A doctor identifies a “spot” on a lung after a routine chest X-ray.  The doctor arranges an appointment with a pulmonologist, who orders a CT scan, reviews it, and announces… it’s just a benign nodule. Nothing to worry about. That’s the happy scenario. The grim truth is that only about 15% of diagnosed lung cancer patients survive longer than 5 years. Lung cancer is a stone cold killer, and 85% of cases are smokers or former smokers. On Wednesday, a research team at the University of New Mexico announced that Celebrex, the controversial Cox-2 inhibitor used for the treatment of arthritis, may inhibit the growth of cells known to be precursors of lung cancer. Test subjects who took celecoxib had a 34% reduction in a protein called KI-67, which is an antigen necessary for cell proliferation, and is used as a marker for monitoring cell growth. In the case of breast and prostate cancer, the fraction of KI-67-positive cells in a tumor has proven to be a useful tool for determining how advanced a cancer is. The team found that the placebo group had a 3.8% increase over the same test period.

A lot more testing needs to be done. One potential problem: Celebrex increases the risk of cardiovascular disease and stroke, so future clinical studies will be limited to smokers with no other cardiovascular risk factors.

Rehabilitation Directories

Most Popular
The Rehab Review
Cliffside Malibu

The “beach-house-relaxed” Cliffside Malibu claims to provide an oasis for recovering addicts and alcoholics. And that’s just what you'll get—if you’ve got the cash.

Morningside Recovery

For a “rehab near the beach” experience that isn’t quite as costly as similar SoCal competitors, head to this Newport Beach treatment facility.

AToN Center

Whether you’re interested in the 12 Steps, SMART Recovery, or holistic treatments, this luxurious, appealing and commendable 4.5 star (our system doesn't yet show the 1/2 star) San Diego rehab has a program for you. 


This exclusive Northern California rehab is all about client choice—as well as golf outings, Buddhist field trips and keeping up with the office.

Capo By The Sea

Capo By The Sea offers an executive rehab program complete with medical detox and a focus on dual-diagnosis issues, as well as an outpatient option in an environment that exudes the kind of beach house optimism one would expect from an Orange County recovery outfit.

Journey Malibu

Want many of the luxury amenities A-listers have come to expect—including an enormous backyard with a pool and patio, an herb garden, a volleyball net and a spectacular vista of the Santa Monica mountains—with a recovery program to match?

The Ultimate Guide to Rehab

What you need to know when choosing an addiction treatment center.

the fix tv